P38 Kinase is a convergence point for multiple signaling pathways involved in inflammation. Because of P38 Kinase's central role, inhibitors of the enzyme have long been sought as potential drugs for a variety of inflammatory diseases.
Mitogen-activated protein kinases (MAPK) are intracellular signaling molecules involved in cytokine synthesis. Several classes of mammalian MAPK have been identified, including extracellular signal-regulated kinase, c-jun N-terminal kinase, and p38 MAP kinase. p38 is a key MAPK involved in tumor necrosis factor and other cytokine production, as well as enzyme induction (cyclooxygenase-2, inducible nitric oxide synthase, and matrix metalloproteinases) and adhesion molecule expression. The role of MAPK in inflammation makes them attractive targets for new therapies.
I. Presentation - General Information
New Treatments For Psoriasis
IV. Originators - In-Licensers - Partners
V. Clinical Trials
VI. SWOT Analysis
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